INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascul...

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Main Authors Jiang Jinlong, Ferguson, II Ronald, Blizzard Timothy A, Shi Zhi-Cai, Suzuki Takao, Pasternak Alexander, Wu Zhicai, Yu Yang, Guo Zhiqiang, Gu Xin, Frie Jessica, Vangelder Kelsey F, Walsh Shawn P, Dong Shuzhi, Fu Qinghong
Format Patent
LanguageEnglish
Published 28.09.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Bibliography:Application Number: US201515505254