Genetic Alterations in Isocitrate Dehydrogenase and Other Genes in Malignant Glioma

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R17...

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Main Authors Parsons D. Williams, Angenendt Philipp, Kuan Chien-Tsun, Velculescu Victor, Karchin Rachel, Zhang Xiaosong, Kinzler Kenneth W, Jones Sian, Papadopoulos Nickolas, Riggins Gregory J, Vogelstein Bert, Lin Jimmy Cheng-Ho, Parmigiani Giovanni, Yan Hai, Leary Rebecca J, Bigner Darell D
Format Patent
LanguageEnglish
Published 23.03.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
Bibliography:Application Number: US201615353002