3-(ARYL OR HETEROARYL) METHYLENEINDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF CANCER STEM CELL PATHWAY KINASES FOR THE TREATMENT OF CANCER

The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R2 is an optionally substitut...

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Bibliographic Details
Main Authors LIU JI-FENG, ROGOFF HARRY, TOJO SHINGO, KANAI TOSHIO, LI WEI, TAKANASHI YOSUKE, KUBOTA KATSUMI, TSUBOI KATSUNORI, LI CHIANG JIA, GIBEAU AMANDA, KODAMA TOMOHIRO
Format Patent
LanguageEnglish
Published 04.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R2 is an optionally substituted heterocycle or optionally substituted aryl; and one of R4, R5, R6 and R7 is a substituted heterocycle or substituted aryl.
Bibliography:Application Number: US201414774803