COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN C-III EXPRESSION
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and me...
Saved in:
| Main Authors | , , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
05.11.2015
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia). |
|---|---|
| AbstractList | The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia). |
| Author | MACDONALD MARCIA MACLACHLAN LAN LEE AMY C.H |
| Author_xml | – fullname: MACDONALD MARCIA – fullname: MACLACHLAN LAN – fullname: LEE AMY C.H |
| BookMark | eNrjYmDJy89L5WRwc_b3DfAP9gzx9PcLVnD0c1HwdQ3x8HcJVnDzD1II9vRx9XP29HNXcAzw9_EM8A8I8g9x9fRTcNb19PRUcI0ICHINDgZq5WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgaGpsaGpqYWJo6GxsSpAgC2NC9k |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | US2015315584A1 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_US2015315584A13 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 13:54:11 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_US2015315584A13 |
| Notes | Application Number: US201514676489 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151105&DB=EPODOC&CC=US&NR=2015315584A1 |
| ParticipantIDs | epo_espacenet_US2015315584A1 |
| PublicationCentury | 2000 |
| PublicationDate | 20151105 |
| PublicationDateYYYYMMDD | 2015-11-05 |
| PublicationDate_xml | – month: 11 year: 2015 text: 20151105 day: 05 |
| PublicationDecade | 2010 |
| PublicationYear | 2015 |
| RelatedCompanies | PROTIVA BIOTHERAPEUTICS, INC |
| RelatedCompanies_xml | – name: PROTIVA BIOTHERAPEUTICS, INC |
| Score | 3.0098562 |
| Snippet | The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN C-III EXPRESSION |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151105&DB=EPODOC&locale=&CC=US&NR=2015315584A1 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3PS8MwFH6MKepNp-J0SkDprbh27ewORbY0dRHblLWT3cbapiBIN1zFf9-30OlOu-UHCcmDL-99Sb4E4AGDcLlwMhMhnhe6lUqpO2Za6EVu2GmWDfKBkkcHYX88tV5n9qwBn1stjHon9Ec9joiIyhDvlVqvV_-bWJ66W7l-TD-waPnsJ66n1ewY3RfGC5o3clkkPEE1St1prIUTVddD3-lYQ-RKBxhIP23wwN5HG13Katep-KdwGGF_ZXUGDVm24Jhu_15rwVFQH3ljskbf-hx8KoJIxFwpf8kw9EjAkrHwYoJUjsT8jYWUhy9kGAnk6yKaiITxkFCdc07YTBkbm17Avc8SOtZxQPO_-c-n8e7oe5fQLJelvALS7XczK7VtaWQLC5mBI9G2poMxnm0sjL7Ths6-nq73V9_AySarhHd2B5rV17e8RQ9cpXfKcL8hrYNk |
| link.rule.ids | 230,309,783,888,25576,76876 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1BT8IwFH4haMSbokYUtYlmt0UGG44DMdB1rsrahQ3DjbBREhMziMz49300oJy4NX1p077k63tf268FeMAkXE3drIkQn81NO1XKdJvp3JzPLCfNss6so-XRoWgHI_t17IxL8LnVwuh3Qn_044iIqAzxXuj1evm_ieXpu5Wrx_QDqxbPftL1jA07xvCF-YLh9bsskp6kBqXdUWyIoba1MHa6dg-50gEm2U9rPLD3_lqXstwNKv4JHEbYX16cQknlVajQ7d9rVTgKN0feWNygb3UGPpVhJGOulb-kJzwSsiSQXkyQypGYD5igXLyQXiSRr8toKBPGBaEm55ywsXY2Nj2He58lNDBxQJO_-U9G8e7oWxdQzhe5ugTSaDcyO3UcZWVTG5mBq9C3TRdzPMeaWm23BvV9PV3tN99BJUjCwWTAxds1HK9NWoTn1KFcfH2rG4zGRXqrnfgLd1KGVw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=COMPOSITIONS+AND+METHODS+FOR+SILENCING+APOLIPOPROTEIN+C-III+EXPRESSION&rft.inventor=MACDONALD+MARCIA&rft.inventor=MACLACHLAN+LAN&rft.inventor=LEE+AMY+C.H&rft.date=2015-11-05&rft.externalDBID=A1&rft.externalDocID=US2015315584A1 |