COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

• Main Authors: SHAW DAVID, STORCK PIERRE-HENRI, ETXEBARRIA I JARDI GORKA, JIMENEZ JUAN-MIGUEL, TWIN HEATHER, DURRANT STEVEN, PIERARD FRANCOISE, KAY DAVID, DAVIS CHRIS, CHARRIER JEAN-DAMIEN, BRENCHLEY GUY, STUDLEY JOHN, PINDER JOANNE, KNEGTEL RONALD, FRAYSSE DAMIEN
• Format: Patent
• Language: English
• Published: 15.10.2015
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ELECTROTHERAPY; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; RADIATION THERAPY; SPIRITS; ULTRASOUND THERAPY; VINEGAR; WINE

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.