NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory actio...

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Main Authors ASAUMI MAKOTO, OKADA HARUKI, KAWAMOTO YUICHIRO, KAMEDA MINORU, KURIWAKI IKUMI, MIYASAKA KOZO, MORITOMO HIROYUKI, SUZUKI ATSUSHI, FUTAMI TAKASHI, TSUNOYAMA KAZUHISA, TOKUZAKI KAZUO, SUZUKI TOMOYUKI, TOMIYAMA HIROSHI, NODA ATSUSHI, IIKUBO KAZUHIKO, HISAMICHI HIROYUKI, IWAI YOSHINORI
Format Patent
LanguageEnglish
Published 22.05.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.
AbstractList Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.
Author KURIWAKI IKUMI
OKADA HARUKI
MIYASAKA KOZO
TSUNOYAMA KAZUHISA
FUTAMI TAKASHI
ASAUMI MAKOTO
IIKUBO KAZUHIKO
TOKUZAKI KAZUO
IWAI YOSHINORI
SUZUKI TOMOYUKI
KAMEDA MINORU
HISAMICHI HIROYUKI
TOMIYAMA HIROSHI
SUZUKI ATSUSHI
NODA ATSUSHI
KAWAMOTO YUICHIRO
MORITOMO HIROYUKI
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– fullname: NODA ATSUSHI
– fullname: IIKUBO KAZUHIKO
– fullname: HISAMICHI HIROYUKI
– fullname: IWAI YOSHINORI
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND
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