Salt Form of a Multi-Arm Polymer-Drug Conjugate

• Main Authors: NIE SHAOYONG, HANDLEY JOHN R, MCMANUS SAMUEL P, SPENCE PATRICK L, LAVATY GREG, CHONG ANTHONY O, SWALLOW DAVID, BRAY BRIAN, KOZLOWSKI ANTONI, SCHAEFER ANTHONY G, JOSHI BHALCHANDRA V, LEE SEOJU, TIPNIS SACHIN
• Format: Patent
• Language: English
• Published: 05.09.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the correspondin...