PROTEIN FORMULATION

A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared...

Full description

Saved in:
Bibliographic Details
Main Authors ANDYA JAMES, LAM XANTHE M, CLELAND JEFFREY L, SHIRE STEVEN J, OVERCASHIER DAVID E, WU SYLVIA SAU-YAN, HSU CHUNG C, YANG JANET YU-FENG
Format Patent
LanguageEnglish
Published 29.08.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

Abstract A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
AbstractList A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
Author SHIRE STEVEN J
WU SYLVIA SAU-YAN
OVERCASHIER DAVID E
HSU CHUNG C
ANDYA JAMES
LAM XANTHE M
CLELAND JEFFREY L
YANG JANET YU-FENG
Author_xml – fullname: ANDYA JAMES
– fullname: LAM XANTHE M
– fullname: CLELAND JEFFREY L
– fullname: SHIRE STEVEN J
– fullname: OVERCASHIER DAVID E
– fullname: WU SYLVIA SAU-YAN
– fullname: HSU CHUNG C
– fullname: YANG JANET YU-FENG
BookMark eNrjYmDJy89L5WQQDgjyD3H19FNw8w_yDfVxDPH09-NhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGhwUYGhsZGRiaGFqaOhsbEqQIAttUhNQ
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2013224185A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2013224185A13
IEDL.DBID EVB
IngestDate Fri Jul 19 16:00:50 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2013224185A13
Notes Application Number: US201213619576
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130829&DB=EPODOC&CC=US&NR=2013224185A1
ParticipantIDs epo_espacenet_US2013224185A1
PublicationCentury 2000
PublicationDate 20130829
PublicationDateYYYYMMDD 2013-08-29
PublicationDate_xml – month: 08
  year: 2013
  text: 20130829
  day: 29
PublicationDecade 2010
PublicationYear 2013
RelatedCompanies SHIRE STEVEN J
WU SYLVIA SAU-YAN
OVERCASHIER DAVID E
HSU CHUNG C
ANDYA JAMES
LAM XANTHE M
CLELAND JEFFREY L
YANG JANET YU-FENG
RelatedCompanies_xml – name: ANDYA JAMES
– name: SHIRE STEVEN J
– name: OVERCASHIER DAVID E
– name: WU SYLVIA SAU-YAN
– name: CLELAND JEFFREY L
– name: HSU CHUNG C
– name: YANG JANET YU-FENG
– name: LAM XANTHE M
Score 2.8997507
Snippet A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title PROTEIN FORMULATION
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130829&DB=EPODOC&locale=&CC=US&NR=2013224185A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSTExN7cwSTLSNUozSNE1AVaQukkplim6qWmWBmmJxkA9yeDTPv3MPEJNvCJMI5gYcmB7YcDnhJaDD0cE5qhkYH4vAZfXBYhBLBfw2spi_aRMoFC-vVuIrYsatHdsCDp8xVLNxcnWNcDfxd9ZzdnZNjRYzS8ILAeqrSxMHYF9JVZgQ9oclB9cw5xA-1IKkCsVN0EGtgCgeXklQgxMqXnCDJzOsLvXhBk4fKFT3kAmNPcVizAIBwT5h7h6-ikAe26-oT7g0SVRBmU31xBnD12g6fFwz8SHBiM7xViMgQXYzU-VYFCwNDJIMzIwN7M0SU41STRKtjBJM0wxNk1MMkgyNja3MJNkkMFnkhR-aWkGLiPwRQ6gPRcyDCwlRaWpssDqtCRJDhwKAHsZdVw
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSTExN7cwSTLSNUozSNE1AVaQukkplim6qWmWBmmJxkA9yeDTPv3MPEJNvCJMI5gYcmB7YcDnhJaDD0cE5qhkYH4vAZfXBYhBLBfw2spi_aRMoFC-vVuIrYsatHdsCDp8xVLNxcnWNcDfxd9ZzdnZNjRYzS8ILAeqrSxMHYF9JVZgI9sclB9cw5xA-1IKkCsVN0EGtgCgeXklQgxMqXnCDJzOsLvXhBk4fKFT3kAmNPcVizAIBwT5h7h6-ikAe26-oT7g0SVRBmU31xBnD12g6fFwz8SHBiM7xViMgQXYzU-VYFCwNDJIMzIwN7M0SU41STRKtjBJM0wxNk1MMkgyNja3MJNkkMFnkhR-aXkGTo8QX594H08_b2kGLiPwpQ6g_RcyDCwlRaWpssCqtSRJDhwiACYbeE8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PROTEIN+FORMULATION&rft.inventor=ANDYA+JAMES&rft.inventor=LAM+XANTHE+M&rft.inventor=CLELAND+JEFFREY+L&rft.inventor=SHIRE+STEVEN+J&rft.inventor=OVERCASHIER+DAVID+E&rft.inventor=WU+SYLVIA+SAU-YAN&rft.inventor=HSU+CHUNG+C&rft.inventor=YANG+JANET+YU-FENG&rft.date=2013-08-29&rft.externalDBID=A1&rft.externalDocID=US2013224185A1