SPIROXAZOLIDINONE COMPOUNDS

• Main Authors: UJJAINWALLA FEROZE, DUFFY JOSEPH L, PLOTKIN MICHAEL A, LIU WEIGUO, ROMERO F. ANTHONY, BAO JIANMING, ZWICKER AARON, SHERER EDWARD C, WOOD HAROLD B, ZANG YI, SHAO PATRICK, TYAGARAJAN SRIRAM, MONINGKA REMOND, ONDEYKA DEBRA L, HUSSAIN ZAHID, KATIPALLY REVATHI, YE FENG, FINKE PAUL E
• Format: Patent
• Language: English
• Published: 23.05.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Substituted spirocyclic amines of structural formula (I) are selective antagonists of the somatostatin subtype receptor 5 (SSTR5) and are useful for the treatment, control or prevention of disorders responsive to antagonism of SSTR5, such as Type 2 diabetes, insulin resistance, lipid disorders, obes...