METHODS FOR PREPARING STATIN COMPOUNDS BY LACTONIZATION
A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal c...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English |
Published |
22.11.2012
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal cations; R1 is H or C1-C6 alkyl, preferably H or CH3, R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3, or COOR4, preferably CH3 or OH, R3 and R4 are independently selected from the group consisting of H and C1-C6 alkyl. |
---|---|
AbstractList | A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a strong acid catalyst and a dehydrant in a first solvent, wherein Z represents H, ammonium, or a metal cations; R1 is H or C1-C6 alkyl, preferably H or CH3, R2 is CH3, OH, CH2OH, CH2OC(O)R3, CH2OR3, or COOR4, preferably CH3 or OH, R3 and R4 are independently selected from the group consisting of H and C1-C6 alkyl. |
Author | MA DEYIN HE QINGKAI ZHANG YUNHUI |
Author_xml | – fullname: MA DEYIN – fullname: ZHANG YUNHUI – fullname: HE QINGKAI |
BookMark | eNrjYmDJy89L5WQw93UN8fB3CVZw8w9SCAhyDXAM8vRzVwgOcQzx9FNw9vcN8A_1A0o7RSr4ODqH-Pt5RgFl_P14GFjTEnOKU3mhNDeDsptriLOHbmpBfnxqcUFicmpeakl8aLCRgaGRkaWZgaWlo6ExcaoADpIrSA |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
ExternalDocumentID | US2012296099A1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_US2012296099A13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 13:54:09 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_US2012296099A13 |
Notes | Application Number: US201013510701 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121122&DB=EPODOC&CC=US&NR=2012296099A1 |
ParticipantIDs | epo_espacenet_US2012296099A1 |
PublicationCentury | 2000 |
PublicationDate | 20121122 |
PublicationDateYYYYMMDD | 2012-11-22 |
PublicationDate_xml | – month: 11 year: 2012 text: 20121122 day: 22 |
PublicationDecade | 2010 |
PublicationYear | 2012 |
RelatedCompanies | MA DEYIN HE QINGKAI ZHANG YUNHUI |
RelatedCompanies_xml | – name: HE QINGKAI – name: MA DEYIN – name: ZHANG YUNHUI |
Score | 2.8753748 |
Snippet | A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
Title | METHODS FOR PREPARING STATIN COMPOUNDS BY LACTONIZATION |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20121122&DB=EPODOC&locale=&CC=US&NR=2012296099A1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bS8MwFD6MKeqbTsXplILStyJL29U-FGnTlk7sBdvK9GW0WQuCdMNV_PuehE73tLckB0IufDmX5HwBuEOlN34wtYVCVENXtIIViDnNVFihobGMbazg8Y4wmgS59jTTZz343OTCCJ7QH0GOiIhiiPdWnNer_yCWK95Wru_LD2xaPvqZ5cqdd8z5ygiRXcfyktiNqUyplady9CJkhLOrmTb6SnvckOZM-96rw_NSVttKxT-G_QT7a9oT6FXNAA7p5u-1ARyE3ZU3Fjv0rU_BCL0siN1UQs9NwqVLbP6UQUozO5tGEo3DJM4jFDtv0rNNsziavosI1Bnc-l5GAwVHMP-b8DxPt4ernkO_WTbVBUjGgumVSspJiTBirEbzaGzUhWbgTqAqrocw2tXT5W7xFRzxKs-0I2QE_fbru7pGlduWN2KlfgFAy373 |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fS8MwED7GFOebTsXp1ILStyJL29U9FGnTjU7XH9hUpi-lzToQpBuu4r_vJWy6p72FOwiXhC-X75K7ANyh0-s9DIyZRnTL1Iyc54g5Y6Dx3MDDMsp4LuIdQdj3U-Npak4b8LnJhZF1Qn9kcUREFEe813K_Xv4HsTz5tnJ1X3ygaPE4YranrtmxqFdGiOq59jCOvIiqlNppooYvUkdEdbWBg1xpz0JSKMnSqyvyUpbbTmV0BPsx9lfVx9Aoqza06ObvtTYcBOsrb2yu0bc6ASsYMj_yEgWZm4JTFzviKYOSMIeNQ4VGQRylIardN2XiUBaF43cZgTqF29GQUV9DC7K_AWdpsm2ufgbNalGV56BYM26WOin6BcKI8zkej3rWPDcsXAl0xfMOdHf1dLFbfQMtnwWTbDIOny_hUKhE1h0hXWjWX9_lFbrfuriWs_YLVdGB4Q |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=METHODS+FOR+PREPARING+STATIN+COMPOUNDS+BY+LACTONIZATION&rft.inventor=MA+DEYIN&rft.inventor=ZHANG+YUNHUI&rft.inventor=HE+QINGKAI&rft.date=2012-11-22&rft.externalDBID=A1&rft.externalDocID=US2012296099A1 |