Pyrimidine Inhibitors of Kinase Activity

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said...

Full description

Saved in:
Bibliographic Details
Main Authors BELL RANDY L, MANTEI ROBERT A, WANG GARY T, BA-MAUNG NWE Y, FIDANZE STEVE D, SHEPPARD GEORGE S, SORENSEN BRYAN K, ERICKSON SCOTT A, CLARK RICHARD F, WANG JIEYI
Format Patent
LanguageEnglish
Published 02.12.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R.
AbstractList The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and Ar2 are defined in the description. The present invention relates also to methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R.
Author SHEPPARD GEORGE S
WANG JIEYI
SORENSEN BRYAN K
CLARK RICHARD F
WANG GARY T
BA-MAUNG NWE Y
BELL RANDY L
ERICKSON SCOTT A
MANTEI ROBERT A
FIDANZE STEVE D
Author_xml – fullname: BELL RANDY L
– fullname: MANTEI ROBERT A
– fullname: WANG GARY T
– fullname: BA-MAUNG NWE Y
– fullname: FIDANZE STEVE D
– fullname: SHEPPARD GEORGE S
– fullname: SORENSEN BRYAN K
– fullname: ERICKSON SCOTT A
– fullname: CLARK RICHARD F
– fullname: WANG JIEYI
BookMark eNrjYmDJy89L5WTQCKgsyszNTMnMS1XwzMvITMosyS8qVshPU_DOzEssTlVwTC7JLMssqeRhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGhwUYGhgbGBqaGRmaOhsbEqQIAXcsq2w
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2010305126A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2010305126A13
IEDL.DBID EVB
IngestDate Fri Jul 19 16:02:21 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2010305126A13
Notes Application Number: US20100788008
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101202&DB=EPODOC&CC=US&NR=2010305126A1
ParticipantIDs epo_espacenet_US2010305126A1
PublicationCentury 2000
PublicationDate 20101202
PublicationDateYYYYMMDD 2010-12-02
PublicationDate_xml – month: 12
  year: 2010
  text: 20101202
  day: 02
PublicationDecade 2010
PublicationYear 2010
RelatedCompanies ABBOTT LABORATORIES
RelatedCompanies_xml – name: ABBOTT LABORATORIES
Score 2.7960365
Snippet The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof, wherein G1, R2, R3, R4, R5, n, p, q, Ar1, and...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Pyrimidine Inhibitors of Kinase Activity
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101202&DB=EPODOC&locale=&CC=US&NR=2010305126A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSbNIAzYSTFN1gb2rZGAHJcVS19LA1FQ32TDZAthaBlY5aaABfV8_M49QE68I0wgmhhzYXhjwOaHl4MMRgTkqGZjfS8DldQFiEMsFvLayWD8pEyiUb-8WYuuiBu0dgw6rMjBSc3GydQ3wd_F3VnN2tg0NVvMLAssBk7ahkZkjsK_ECmpIg07adw1zAu1LKUCuVNwEGdgCgObllQgxMKXmCTNwOsPuXhNm4PCFTnkDmdDcVyzCoBFQCbqEC1jbpCp45mVkJmWCrspRyE9T8M7MA9ZGCo7JkLsgRBmU3VxDnD10gVbGw30YHxqM7D5jMQYWYN8_VYJBwczA2DTFzCIt1QJ0bHyScVKyRaKRhSGwj5BiamSRZi7JIIPPJCn80tIMXEaw1RlGMgwsJUWlqbLAOrYkSQ4cNABJTH16
link.rule.ids 230,309,786,891,25594,76903
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSbNIAzYSTFN1gb2rZGAHJcVS19LA1FQ32TDZAthaBlY5aaABfV8_M49QE68I0wgmhhzYXhjwOaHl4MMRgTkqGZjfS8DldQFiEMsFvLayWD8pEyiUb-8WYuuiBu0dgw6rMjBSc3GydQ3wd_F3VnN2tg0NVvMLAssBk7ahkZkjsK_Eag7sFII7S2FOoH0pBciVipsgA1sA0Ly8EiEGptQ8YQZOZ9jda8IMHL7QKW8gE5r7ikUYNAIqQZdwAWubVAXPvIzMpEzQVTkK-WkK3pl5wNpIwTEZcheEKIOym2uIs4cu0Mp4uA_jQ4OR3WcsxsAC7PunSjAomBkYm6aYWaSlWoCOjU8yTkq2SDSyMAT2EVJMjSzSzCUZZPCZJIVfWp6B0yPE1yfex9PPW5qBywi2UsNIhoGlpKg0VRZY35YkyYGDCQBMmoBk
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Pyrimidine+Inhibitors+of+Kinase+Activity&rft.inventor=BELL+RANDY+L&rft.inventor=MANTEI+ROBERT+A&rft.inventor=WANG+GARY+T&rft.inventor=BA-MAUNG+NWE+Y&rft.inventor=FIDANZE+STEVE+D&rft.inventor=SHEPPARD+GEORGE+S&rft.inventor=SORENSEN+BRYAN+K&rft.inventor=ERICKSON+SCOTT+A&rft.inventor=CLARK+RICHARD+F&rft.inventor=WANG+JIEYI&rft.date=2010-12-02&rft.externalDBID=A1&rft.externalDocID=US2010305126A1