COMPOUND CAPABLE OF INHIBITING 17-BETA HYDROXYSTERIOD DEHYDROGENASE
There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally subs...
Saved in:
Main Authors | , , , , , |
---|---|
Format | Patent |
Language | English |
Published |
11.11.2010
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) -SO2-alkyl; and (n) -N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S( O)2, C O, S( O)2NR16, C ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups. |
---|---|
AbstractList | There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) -SO2-alkyl; and (n) -N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S( O)2, C O, S( O)2NR16, C ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups. |
Author | DAY JOANNA MARY PUROHIT ATUL POTTER BARRY VICTOR LLOYD VICKER NIGEL HEATON WESLEY BAILEY HELEN VICTORIA |
Author_xml | – fullname: BAILEY HELEN VICTORIA – fullname: DAY JOANNA MARY – fullname: POTTER BARRY VICTOR LLOYD – fullname: PUROHIT ATUL – fullname: VICKER NIGEL – fullname: HEATON WESLEY |
BookMark | eNrjYmDJy89L5WRwdvb3DfAP9XNRcHYMcHTycVXwd1Pw9PPwdPIM8fRzVzA013VyDXFU8Ih0CfKPiAwOcQ3y9HdRcHEFC7i7-jkGu_IwsKYl5hSn8kJpbgZlN9cQZw_d1IL8-NTigsTk1LzUkvjQYCMDQwMjCzMjAxNHQ2PiVAEA7jQuGQ |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
ExternalDocumentID | US2010286204A1 |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_US2010286204A13 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 16:01:10 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_US2010286204A13 |
Notes | Application Number: US20080744044 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101111&DB=EPODOC&CC=US&NR=2010286204A1 |
ParticipantIDs | epo_espacenet_US2010286204A1 |
PublicationCentury | 2000 |
PublicationDate | 20101111 |
PublicationDateYYYYMMDD | 2010-11-11 |
PublicationDate_xml | – month: 11 year: 2010 text: 20101111 day: 11 |
PublicationDecade | 2010 |
PublicationYear | 2010 |
RelatedCompanies | STERIX LIMITED |
RelatedCompanies_xml | – name: STERIX LIMITED |
Score | 2.7943666 |
Snippet | There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3,... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
Title | COMPOUND CAPABLE OF INHIBITING 17-BETA HYDROXYSTERIOD DEHYDROGENASE |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101111&DB=EPODOC&locale=&CC=US&NR=2010286204A1 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dS8MwMIwp6ptOxY8pAaVvRbtuafcwpE3SteKasrayPY3UpiBIN1zFv28SNvVpb-EOjkvgct93ANwjxDkqnaFZVlVp9rnFzaLnCvPRGZa2cGy7LFRAfxKjMO8_zwazFvjY9sLoOaHfejiilKg3Ke-N_q9Xf0Esomsr1w_FuwQtn4JsRIyNd2ypzemWQfwRTRhh2MB4lKdGPNW4nquGr3vSV9pThrSatE9ffdWXsvqvVIJjsJ9IenVzAlqi7oBDvN291gEHk03KWx430rc-BRizScLymEDsJZ7_QiELYBSHkR9lUTyGUhP4NPNgOCdTNpun0lKNGIGEasCYxl5Kz8BdQDMcmpKbxe_lF3n6n3X7HLTrZS0uAOTScUNoaImSC9U-6yJ30OdFVXHbGjh2dQm6uyhd7UZfgyOdJ1cFb1YXtJvPL3Ej1W9T3OpX-wHuSIJR |
link.rule.ids | 230,309,786,891,25594,76906 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dS8Mw8BhTnG86FT-mFpS-Fe26td3DkDZJ1-r6wdrK9jTStQVBuuEq_n2TsOme9hbu4LgELvd9B_Co65TquTFQ8rLMlR5VqZJ1zUJ5Nga5Vhialmc8oO8Hupv2Xqf9aQM-t70wYk7ojxiOyCRqweS9Fv_16j-IhUVt5fop-2Cg5YuTDLG88Y5VvjldlbE9JFGIQyQjNExjOZgIXNfkw9ct5isdGHw-Lzee3m3el7LaVSrOCRxGjF5Vn0KjqNrQQtvda2048jcpb3bcSN_6DBAK_ShMAywhK7LsMZFCR_IC17O9xAtGEtMENkksyZ3hSTidxcxS9UIsYSIAIxJYMTmHB4ckyFUYN_O_y8_TeJd17QKa1bIqLkGizHHT9YFa5LTg7bOmbvZ7NCtLqql9QyuvoLOP0vV-9D203MQfz8de8HYDxyJnzovf1A4066_v4pap4jq7Ey_4Cy-ghT4 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=COMPOUND+CAPABLE+OF+INHIBITING+17-BETA+HYDROXYSTERIOD+DEHYDROGENASE&rft.inventor=BAILEY+HELEN+VICTORIA&rft.inventor=DAY+JOANNA+MARY&rft.inventor=POTTER+BARRY+VICTOR+LLOYD&rft.inventor=PUROHIT+ATUL&rft.inventor=VICKER+NIGEL&rft.inventor=HEATON+WESLEY&rft.date=2010-11-11&rft.externalDBID=A1&rft.externalDocID=US2010286204A1 |