SYNTHETIC LUNG SURFACTANT AND USE THEREOF
The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all...
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Format | Patent |
Language | English |
Published |
04.03.2010
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Abstract | The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed. |
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AbstractList | The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed. |
Author | DAVY JASON A WANG ZHONGYI WANG ZHENGDONG WALTHER FRANS NOTTER ROBERT H WARING ALAN J GORDON LARRY M SCHWAN ADRIAN L |
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RelatedCompanies | UNIVERSITY OF GUELPH THE LOS ANGELES BIOMEDICAL RESEARCH LIMITED AT HARBOR-UCLA MEDICAL CENTER A UNIVERSITY UNIVERSITY OF ROCHESTER |
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Title | SYNTHETIC LUNG SURFACTANT AND USE THEREOF |
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