SYNTHETIC LUNG SURFACTANT AND USE THEREOF

The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all...

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Main Authors SCHWAN ADRIAN L, DAVY JASON A, GORDON LARRY M, NOTTER ROBERT H, WALTHER FRANS, WARING ALAN J, WANG ZHENGDONG, WANG ZHONGYI
Format Patent
LanguageEnglish
Published 04.03.2010
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Abstract The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
AbstractList The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.
Author DAVY JASON A
WANG ZHONGYI
WANG ZHENGDONG
WALTHER FRANS
NOTTER ROBERT H
WARING ALAN J
GORDON LARRY M
SCHWAN ADRIAN L
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RelatedCompanies UNIVERSITY OF GUELPH
THE LOS ANGELES BIOMEDICAL RESEARCH LIMITED AT HARBOR-UCLA MEDICAL CENTER A UNIVERSITY
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Snippet The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives,...
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title SYNTHETIC LUNG SURFACTANT AND USE THEREOF
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