Process for Remifentanil Synthesis

A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of a synthetic opiate or opioid compound by alkylating a substituted 4-piperidine in the presence of a base to form an intermediate that is further alkylated with an electrophilic alkylating a...

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Bibliographic Details
Main Authors HALVACHS ROBERT E, CHENG BRIAN KAI-MING
Format Patent
LanguageEnglish
Published 25.02.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of a synthetic opiate or opioid compound by alkylating a substituted 4-piperidine in the presence of a base to form an intermediate that is further alkylated with an electrophilic alkylating agent and acylated to produce the compound.
Bibliography:Application Number: US20070515958