ORGANIC COMPOUNDS

• Main Authors: JACOBY EDGAR, MARZINZIK ANDREAS, ERHARDT CLAUS, BREITENSTEIN WERNER, KAWAKAMI SHIMPEI, OSTERMANN NILS, KONISHI KAZUHIDE, YOKOKAWA FUMIAKI, KANAZAWA TAKANORI, GROSCHE PHILIPP, MAIBAUM JUERGEN KLAUS, MASUYA KEIICHI, ZIMMERMANN JUERG
• Format: Patent
• Language: English
• Published: 17.09.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.