PROCESS FOR THE PREPARTION OF OLANZAPINE

• Main Authors: NEMETH GABOR, KOVANYINE LAX GYORGYI, NAGY KALMAN, KRASZNAY GYORGY, MESTERHAZY NORBERT, VERECZKEYNE DONATH GYORGYI, SZENT-KIRALLYI ZSUZSANNA
• Format: Patent
• Language: English
• Published: 28.05.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a process for the preparation of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno-[2,3-b][1,5]benzodiazepine (olanzapine) of the formula (I) by reacting 4-amino-2-methyl-10H-thieno [2,3-b][1/5]benzodiazepine hydrochloride of the formula (II) with N-methylpiperazine in an organ...