GIP ANALOG AND HYBRID POLYPEPTIDES WITH SELECTABLE PROPERTIES

The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/...

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Main Authors SOARES CHRISTOPHER J, LEVY ODILE ESTHER, GHOSH SOUMITRA S, JODKA CAROLYN M, YOUNG ANDREW A, LE THAO, PITTNER RICHARD A, BARON ALAIN D, MACK CHRISTINE M, JANSSEN SAMUEL, SRIVASTAVA VED, LEWIS DIANA Y, D'SOUZA LAWRENCE J, PARKES DAVID G, HANLEY MICHAEL R, ERICKSON MARY
Format Patent
LanguageEnglish
Published 18.12.2008
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and/or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
Bibliography:Application Number: US20070840921