Methods and compositions of novel triazine compounds

• Main Authors: SAXENA UDAY, TIMMER RICHARD T, YELESWARAPU KOTESWAR R, PAL MANOJIT, KUMAR POTLAPALLY R, KRISHNA REDDY VELAGALA VENKATA RAMA M, ALLURI SESHA S, ALEXANDER CHRISTOPHER W, REDDY JANGALGAR T, PILLARISETTI SIVARAM, REDDY GADDAM O
• Format: Patent
• Language: English
• Published: 24.05.2007
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.