Interleukin-1 muteins useful as vaccine adjuvants
The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example, muteins of IL-1beta can be used according to the invention. The mutein composition can include a vacci...
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| Main Authors | , |
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| Format | Patent |
| Language | English |
| Published |
16.12.2004
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| Edition | 7 |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example, muteins of IL-1beta can be used according to the invention. The mutein composition can include a vaccine antigen, such as whole inactivated or attenuated virus, recombinant or synthetic peptides, and other antigenic materials. The present invention also pertains to the use of an IL-1 mutein in a human or animal as an adjuvant to increase immune responses to an antigen or other material to which an immune response is desired. |
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| AbstractList | The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when administered to a human or animal. For example, muteins of IL-1beta can be used according to the invention. The mutein composition can include a vaccine antigen, such as whole inactivated or attenuated virus, recombinant or synthetic peptides, and other antigenic materials. The present invention also pertains to the use of an IL-1 mutein in a human or animal as an adjuvant to increase immune responses to an antigen or other material to which an immune response is desired. |
| Author | DONDERO RICHARD S STAATS HERMAN F |
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| Snippet | The present invention concerns compositions comprising an IL-1 mutein that is useful as an adjuvant for stimulating a controlled immune response when... |
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| Title | Interleukin-1 muteins useful as vaccine adjuvants |
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