Crystalline forms of ertapenem sodium

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...

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Main Authors BRANDS KAREL M. J, WILLIAMS JOHN M, FISHER ELIZABETH S, CVETOVICH RAYMOND, WARD MICHAEL D, CROCKER LOUIS S, ORELLA CHARLES, MAHAJAN AMAR J, WENSLOW ROBERT M, SIDLER DANIEL R
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LanguageEnglish
Published 25.11.2004
Edition7
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Abstract A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C.
AbstractList A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C.
Author WARD MICHAEL D
CVETOVICH RAYMOND
WILLIAMS JOHN M
BRANDS KAREL M. J
FISHER ELIZABETH S
WENSLOW ROBERT M
MAHAJAN AMAR J
CROCKER LOUIS S
SIDLER DANIEL R
ORELLA CHARLES
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– fullname: MAHAJAN AMAR J
– fullname: WENSLOW ROBERT M
– fullname: SIDLER DANIEL R
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CVETOVICH RAYMOND
WILLIAMS JOHN M
BRANDS KAREL M. J
FISHER ELIZABETH S
WENSLOW ROBERT M
MAHAJAN AMAR J
CROCKER LOUIS S
SIDLER DANIEL R
ORELLA CHARLES
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Snippet A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Crystalline forms of ertapenem sodium
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