Crystalline forms of ertapenem sodium

A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containin...

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Main Authors BRANDS KAREL M. J, WILLIAMS JOHN M, FISHER ELIZABETH S, CVETOVICH RAYMOND, WARD MICHAEL D, CROCKER LOUIS S, ORELLA CHARLES, MAHAJAN AMAR J, WENSLOW ROBERT M, SIDLER DANIEL R
Format Patent
LanguageEnglish
Published 25.11.2004
Edition7
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Summary:A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than -5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between -5 and -25° C.
Bibliography:Application Number: US20020485319