Device and methods for directed synthesis of chemical libraries

• Main Authors: JOHNSTON ANGUS, BATTERSBY BRONWYN J, WAY JEFFERY C, MILLER CHRISTOPHER R, TRAU MATHIAS
• Format: Patent
• Language: English
• Published: 25.09.2003
• Edition: 7
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMBINATORIAL CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods a...