Device and methods for directed synthesis of chemical libraries

The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods a...

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Main Authors JOHNSTON ANGUS, BATTERSBY BRONWYN J, WAY JEFFERY C, MILLER CHRISTOPHER R, TRAU MATHIAS
Format Patent
LanguageEnglish
Published 25.09.2003
Edition7
Subjects
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
COMBINATORIAL CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Abstract The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.
AbstractList The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.
Author MILLER CHRISTOPHER R
BATTERSBY BRONWYN J
WAY JEFFERY C
TRAU MATHIAS
JOHNSTON ANGUS
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BATTERSBY BRONWYN J
WAY JEFFERY C
TRAU MATHIAS
JOHNSTON ANGUS
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Snippet The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention...
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SubjectTerms APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
COMBINATORIAL CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
Title Device and methods for directed synthesis of chemical libraries
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