27419, a novel human arginine-N-methyl transferase and uses thereof

• Main Author: MEYERS RACHEL
• Format: Patent
• Language: English
• Published: 11.07.2002
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention provides isolated nucleic acids molecules, designated 27419 nucleic acid molecules, which encode novel methyltransferase family members, preferably arginine methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27419 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27419 gene has been introduced or disrupted. The invention still further provides isolated 27419 proteins, fusion proteins, antigenic peptides and anti-27419 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.