Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof

The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/...

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Main Authors Lee, Jaekyoo, Koh, Jong Sung, Seung, Sang-Ae, Yong, Miyong, Lee, Wongil, Choi, Yunggeun, Hwang, So Young, Kim, Sewon, Liu, Yan, Devine, William G, Diebold, R. Bruce
Format Patent
LanguageEnglish
Published 20.08.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.
AbstractList The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives, and methods for using the derivatives and/or compositions.
Author Liu, Yan
Lee, Jaekyoo
Koh, Jong Sung
Choi, Yunggeun
Kim, Sewon
Hwang, So Young
Seung, Sang-Ae
Lee, Wongil
Diebold, R. Bruce
Yong, Miyong
Devine, William G
Author_xml – fullname: Lee, Jaekyoo
– fullname: Koh, Jong Sung
– fullname: Seung, Sang-Ae
– fullname: Yong, Miyong
– fullname: Lee, Wongil
– fullname: Choi, Yunggeun
– fullname: Hwang, So Young
– fullname: Kim, Sewon
– fullname: Liu, Yan
– fullname: Devine, William G
– fullname: Diebold, R. Bruce
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Snippet The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light...
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SubjectTerms ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Selective inhibitors of ROCK1 and ROCK2 protein kinases and uses thereof
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