Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors

Provided herein are compounds of the Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseas...

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Main Authors Blake, James F, Ren, Li, Andrews, Steven W, Jiang, Yutong, Moreno, David A, Walls, Shane M, Haas, Julia, Kolakowski, Gabrielle R
Format Patent
LanguageEnglish
Published 26.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract Provided herein are compounds of the Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
AbstractList Provided herein are compounds of the Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
Author Moreno, David A
Jiang, Yutong
Walls, Shane M
Blake, James F
Ren, Li
Haas, Julia
Kolakowski, Gabrielle R
Andrews, Steven W
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– fullname: Moreno, David A
– fullname: Walls, Shane M
– fullname: Haas, Julia
– fullname: Kolakowski, Gabrielle R
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Snippet Provided herein are compounds of the Formula I:and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
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