Compositions and methods related to anti-CD19 antibody drug conjugates

• Main Authors: Ryu, Hyun Min, Park, Yun Hee, Oh, Yeong Soo, Kim, Sung Min, Kim, Hyoung Rae, Kim, Yong Zu, Deehan, Maureen, Fischer, Nicolas, Oh, Ji Hye, Song, Ho Young, Chae, Jeiwook
• Format: Patent
• Language: English
• Published: 28.11.2023
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SUGARS

The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.