Processes for preparing TPH1 inhibitors
The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the intermediates, salts, and TPH inhibitors are also provided.
Saved in:
| Main Authors | , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
25.07.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the intermediates, salts, and TPH inhibitors are also provided. |
|---|---|
| AbstractList | The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the intermediates, salts, and TPH inhibitors are also provided. |
| Author | Goldberg, Daniel R De Lombaert, Stéphane |
| Author_xml | – fullname: De Lombaert, Stéphane – fullname: Goldberg, Daniel R |
| BookMark | eNrjYmDJy89L5WRQDyjKT04tLk4tVkjLL1IoKEotSCzKzEtXCAnwMFTIzMvITMosyS8q5mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8aHBhobmBhbGZqZORsbEqAEAdNQpnA |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | US11708365B2 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_US11708365B23 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 14:26:31 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_US11708365B23 |
| Notes | Application Number: US202117149070 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230725&DB=EPODOC&CC=US&NR=11708365B2 |
| ParticipantIDs | epo_espacenet_US11708365B2 |
| PublicationCentury | 2000 |
| PublicationDate | 20230725 |
| PublicationDateYYYYMMDD | 2023-07-25 |
| PublicationDate_xml | – month: 07 year: 2023 text: 20230725 day: 25 |
| PublicationDecade | 2020 |
| PublicationYear | 2023 |
| RelatedCompanies | ALTAVANT SCIENCES GmbH |
| RelatedCompanies_xml | – name: ALTAVANT SCIENCES GmbH |
| Score | 3.4882913 |
| Snippet | The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| Title | Processes for preparing TPH1 inhibitors |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230725&DB=EPODOC&locale=&CC=US&NR=11708365B2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQMUpLS0wD1pS6oJNadE0sLcx0LYG1mK5hmiGwtW2WaGGaCBrQ9_Uz8wg18YowjWBiyILthQGfE1oOPhwRmKOSgfm9BFxeFyAGsVzAayuL9ZMygUL59m4hti5q0N4xaFWzkamai5Ota4C_i7-zmrOzbWiwml-QLeiCFQtjM1MnYHHNCmpGg87Zdw1zAu1KKUCuUtwEGdgCgKbllQgxMKXmCTNwOsNuXhNm4PCFTngDmdC8VyzCoA5d059arABsaCoUFKWCLhDMS1cICfAwVMjMy8hMygRdnSPKoOjmGuLsoQu0MR7uvfjQYITjjMUYWIDd_lQJBgWTVLNE02SgQ9PSUkwsU0EVdzKwbk5JsTSxMEqxSJZkkMJtjhQ-SWkGLlBQgUYojUxlGFhKikpTZYFVa0mSHDhMAPmEfAU |
| link.rule.ids | 230,309,786,891,25594,76903 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT4MwEL8s0zjfdGp0fmFi8IkYGEV4ICbACOpgxIHZG2FQFB-QDIz_vteGOV_0rWmTa3vJ3a93vQ-Aa6Uo0gKRUmKVWiTV0DXJQBST5ELG17aW6iRlDn0_0LxYfVyQRQ_e17kwvE7oFy-OiBKVoby3XF_XGyeWw2Mrm9tliVMf925kOmJnHbOoZoWIjmVOwpkzs0XbNuO5GDybrMGKPtaIhep66w5NQm4qvVgsK6X-DSnuHmyHSK1q96FHqyEM7HXntSHs-N2HNw472WsO4KaL6aeNgA9NoV5R1kCwehWi0JOFsnorlyVrnXMIV-4ksj0Jd0x-rpfE883hxkfQR7OfHoOgUi0lGTHUoshVgzLgzhCb89xQdSXXsxMY_U1n9N_iJQy8yJ8m04fg6RR2GduYt1IhZ9BvV5_0HGG2XV5w_nwD6rp-7w |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Processes+for+preparing+TPH1+inhibitors&rft.inventor=De+Lombaert%2C+St%C3%A9phane&rft.inventor=Goldberg%2C+Daniel+R&rft.date=2023-07-25&rft.externalDBID=B2&rft.externalDocID=US11708365B2 |