Cyclic di-nucleotide compounds as sting agonists
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING act...
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| Main Authors | , , , , , , , , |
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| Format | Patent |
| Language | English |
| Published |
27.06.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. |
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| AbstractList | A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. |
| Author | Childers, Matthew Lloyd Bennett, Frank Wu, Wen-Lian Chang, Wonsuk Cumming, Jared N Lu, Min Lim, Jongwon Andresen, Brian M Trotter, Benjamin Wesley |
| Author_xml | – fullname: Lu, Min – fullname: Trotter, Benjamin Wesley – fullname: Chang, Wonsuk – fullname: Cumming, Jared N – fullname: Bennett, Frank – fullname: Lim, Jongwon – fullname: Wu, Wen-Lian – fullname: Andresen, Brian M – fullname: Childers, Matthew Lloyd |
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| RelatedCompanies | Merck Sharp & Dohme Corp Cumming Jared N Bennett Frank Trotter Benjamin Wesley Merck Sharp & Dohme LLC Chang Wonsuk Childers Matthew Lloyd Andresen Brian M Lim Jongwon Lu Min Wu Wen-Lian |
| RelatedCompanies_xml | – name: Andresen Brian M – name: Cumming Jared N – name: Lim Jongwon – name: Wu Wen-Lian – name: Trotter Benjamin Wesley – name: Merck Sharp & Dohme Corp – name: Bennett Frank – name: Chang Wonsuk – name: Lu Min – name: Childers Matthew Lloyd – name: Merck Sharp & Dohme LLC |
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| Snippet | A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Za, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6,... |
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| SubjectTerms | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| Title | Cyclic di-nucleotide compounds as sting agonists |
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