Tricyclic compounds as histone methyltransferase inhibitors
The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell di...
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
30.05.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. |
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| AbstractList | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds. |
| Author | Zancanella, Manuel Li, Zhe Yu, Ming Xu, Qing |
| Author_xml | – fullname: Li, Zhe – fullname: Xu, Qing – fullname: Zancanella, Manuel – fullname: Yu, Ming |
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| Snippet | The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the... |
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| Title | Tricyclic compounds as histone methyltransferase inhibitors |
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