NLRP3 inflammasome inhibitors

The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical com...

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Main Authors Gommermann, Nina, Mattes, Henri, Mackay, Angela, Solovay, Catherine Fooks, Velcicky, Juraj, Farady, Christopher, Stiefl, Nikolaus Johannes, von Matt, Anette, Janser, Philipp, Smith, Nichola, Vangrevelinghe, Eric
Format Patent
LanguageEnglish
Published 28.12.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Abstract The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
AbstractList The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit NOD-like receptor protein 3 (NLRP3) inflammasome activity. The invention further relates to the processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3.
Author von Matt, Anette
Vangrevelinghe, Eric
Stiefl, Nikolaus Johannes
Gommermann, Nina
Solovay, Catherine Fooks
Smith, Nichola
Mattes, Henri
Farady, Christopher
Janser, Philipp
Mackay, Angela
Velcicky, Juraj
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– fullname: Velcicky, Juraj
– fullname: Farady, Christopher
– fullname: Stiefl, Nikolaus Johannes
– fullname: von Matt, Anette
– fullname: Janser, Philipp
– fullname: Smith, Nichola
– fullname: Vangrevelinghe, Eric
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Snippet The present invention relates to novel pyridazin-3-yl phenol compounds of Formula (I):wherein R1, R2, R3, R4, R5 and Z are defined herein, which inhibit...
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HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Title NLRP3 inflammasome inhibitors
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