Engineered opsonin for pathogen detection and treatment
The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An asp...
Saved in:
| Main Authors | , , |
|---|---|
| Format | Patent |
| Language | English |
| Published |
21.12.2021
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis. |
|---|---|
| AbstractList | The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis. |
| Author | Super, Michael Way, Jeffrey Charles Ingber, Donald E |
| Author_xml | – fullname: Way, Jeffrey Charles – fullname: Ingber, Donald E – fullname: Super, Michael |
| BookMark | eNqNyjsOwjAQBUAXUPC7w3IAJBJL0IOC6IE6suKXxBK8tey9v2g4ANU0s3YLKrFy545TIlAQRXNVJsqoRXKwWSdQIgyDJaUERrGCYB_Qtm45hnfF7ufG7W_d83o_IGuPmsMAwvrXo2naoz-1_tL6f84X_aEwEw |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences Physics |
| ExternalDocumentID | US11203623B2 |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_US11203623B23 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 14:22:44 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_US11203623B23 |
| Notes | Application Number: US202016892575 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211221&DB=EPODOC&CC=US&NR=11203623B2 |
| ParticipantIDs | epo_espacenet_US11203623B2 |
| PublicationCentury | 2000 |
| PublicationDate | 20211221 |
| PublicationDateYYYYMMDD | 2021-12-21 |
| PublicationDate_xml | – month: 12 year: 2021 text: 20211221 day: 21 |
| PublicationDecade | 2020 |
| PublicationYear | 2021 |
| RelatedCompanies | PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
| RelatedCompanies_xml | – name: PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
| Score | 3.3791533 |
| Snippet | The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| Title | Engineered opsonin for pathogen detection and treatment |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211221&DB=EPODOC&locale=&CC=US&NR=11203623B2 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1bS8MwFD6MeX3Tqui8EEH6VlzTrm4PReiNIeyCW2Vvo0kz2B7SYSv-fU9Cu_mirzkQkkPOLfnyHYAnxpjqU9S3uq47sFzP7VrMdriF0Z0LO89Errk7R2NvmLpvi96iBZvmL4zmCf3W5IhoURztvdL-eru_xIo0trJ8ZmscKl6TuR-ZdXWM1QylthkFfjydRJPQDEM_nZnjdx8Fylc7AbrrA5VGK579-CNQv1K2v0NKcgaHU5xNVufQEtKAk7DpvGbA8ah-8DbgSCM0eYmDtRWWF_DSkAiKnBQKzbGWBHNPoroLF3ggSC4qjbCSJJM52WHJL-Exiefh0MK1LHcbX6az_bKdK2jLQoprIIxShlmAy7iqHhwnY8zrM6yzViva4wPvBjp_z9P5T3gLp0qJCq5B7TtoV59f4h6DbsUetLZ-AHqVhjA |
| link.rule.ids | 230,309,786,891,25594,76906 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NT8IwFH8h-IE3nRrFr5qY3RZZNwYcFpNtkKlsENkMN0K3kuChIzLjv-9rw8CLXvuSpn3p-2p__T2AB8aY7FPUNVq23TNsx24ZzLQyA6N7xs18znPF3RnFTpjaL9P2tAYf1V8YxRP6rcgR0aIytPdS-evV7hIrUNjK9SNb4lDxNEjcQN9Ux1jNUGrqgef2x6Ng5Ou-76YTPX5zUSB9teWhu97rSHZemTq9e_JXyup3SBkcw_4YZxPlCdS40KDhV53XNDiMNg_eGhwohGa2xsGNFa5PoVORCPKcFBLNsRQEc08iuwsXeCBIzkuFsBJkLnKyxZKfwf2gn_ihgWuZbTc-Sye7ZVvnUBeF4BdAGKUMswCbZbJ6sKw5Y06XYZ21WNB21nMuofn3PM3_hHfQCJNoOBs-x69XcCQVKqEb1LyGevn5xW8wAJfsVmnuB-oKiR0 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Engineered+opsonin+for+pathogen+detection+and+treatment&rft.inventor=Way%2C+Jeffrey+Charles&rft.inventor=Ingber%2C+Donald+E&rft.inventor=Super%2C+Michael&rft.date=2021-12-21&rft.externalDBID=B2&rft.externalDocID=US11203623B2 |