Combination therapy with glutaminase inhibitors and immuno-oncology agents

• Main Authors: Bennett, Mark K, Bromley, Susan D, Parlati, Francesco, Molineaux, Susan M, Gross, Matthew I
• Format: Patent
• Language: English
• Published: 09.03.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an immuno-oncology therapeutic agent, such as an inhibitor of arginase, CTLA-4, indoleamine 2,3-dioxygenase, and/or PD-1/PD-L1...