Drug-conjugates with a targeting molecule and two different drugs

• Main Authors: Chen, Gang, Khasanov, Alisher B, Chucholowski, Alexander, Zhu, Tong, Miao, Zhenwei, Zhang, Hong D, Hong, Yufeng
• Format: Patent
• Language: English
• Published: 17.11.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

There is disclosed an improved ADC (antibody drug conjugate) type composition having at least two different drug payloads conjugated to a single targeting protein. More specifically, the present disclosure attaches a first drug conjugate to a dual Cysteine residue on a targeting protein and a second...