Substituted naphtho[2,3-b]furans as water-soluble prodrugs for preventing and/or treating cancer

A process for producing a hydrate of a hydrochloride salt of 2,2′-(((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid of the formula:wherein the process comprises the following step:recrystallizing the hydrochloride salt of...

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Bibliographic Details
Main Authors Li, Chiang Jia, Ban, Hitoshi, Sawayama, Yusuke, Kamioka, Seiji
Format Patent
LanguageEnglish
Published 13.10.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for producing a hydrate of a hydrochloride salt of 2,2′-(((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid of the formula:wherein the process comprises the following step:recrystallizing the hydrochloride salt of 2,2′-(((2-acetylnaphtho[2,3-b]furan-4,9-diyl)bis(oxy))bis(carbonyl))bis(azanediyl))bis(ethane-2,1-diyl))bis(azanediyl))diacetic acid, in the presence of hydrochloric acid and a recrystallization solvent;wherein the recrystallization solvent is methanol, ethanol, 2-propanol, diethyl ether, ethyl acetate, benzene, toluene, acetone, dichloromethane, chloroform, hexane, dimethylformamide, acetonitrile, or water; or mixed solvent thereof.
Bibliography:Application Number: US201816194525