Substituted quinazolinones for inhibiting PI3K
The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for treating hematologic neoplasms or liver diseases, containing the quinazolinone derivatives, wherein the novel quinazolinone derivatives accor...
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| Format | Patent |
| Language | English |
| Published |
03.03.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for treating hematologic neoplasms or liver diseases, containing the quinazolinone derivatives, wherein the novel quinazolinone derivatives according to the present invention have a beneficial effect in the treatment of hematologic neoplasms or liver diseases. Particularly, the quinazolinone derivatives inhibit PI3K´ with high selectivity compared to that of a conventional anticancer drug of PI3K´ inhibitors, thereby significantly reducing immunotoxicity, or simultaneously inhibit PI3K´ and PI3K³, thereby enabling the treatment of autoimmune diseases, and anticancer therapy for blood cancer and the like. These targeted drugs have an advantage of enabling the problem of side effects of a conventional highly toxic anticancer therapy to be resolved. |
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| AbstractList | The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for treating hematologic neoplasms or liver diseases, containing the quinazolinone derivatives, wherein the novel quinazolinone derivatives according to the present invention have a beneficial effect in the treatment of hematologic neoplasms or liver diseases. Particularly, the quinazolinone derivatives inhibit PI3K´ with high selectivity compared to that of a conventional anticancer drug of PI3K´ inhibitors, thereby significantly reducing immunotoxicity, or simultaneously inhibit PI3K´ and PI3K³, thereby enabling the treatment of autoimmune diseases, and anticancer therapy for blood cancer and the like. These targeted drugs have an advantage of enabling the problem of side effects of a conventional highly toxic anticancer therapy to be resolved. |
| Author | Hong, Suji Kim, Jongwoo Lee, Chiwoo |
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| Snippet | The present invention relates to novel quinazolinone derivatives inhibiting PI3K; a method for preparing the derivatives; and a pharmaceutical composition for... |
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| Title | Substituted quinazolinones for inhibiting PI3K |
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