5-[(piperazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione derivatives as ADAMTS inhibitors for the treatment of osteoarthritis

The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage an...

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Bibliographic Details
Main Authors Alvey, Luke Jonathan, De Ceuninck, Frédéric André, Deprez, Pierre Marc Marie Joseph, Amantini, David, Peixoto, Christophe, Brebion, Franck Laurent, Jary, Hélène Marie, Pop-Botez, Iuliana Ecaterina, Gosmini, Romain Luc Marie, Varin, Marie Laurence Claire
Format Patent
LanguageEnglish
Published 26.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds inhibiting ADAMTS, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory conditions, and/or diseases involving degradation of cartilage and/or disruption of cartilage homeostasis by administering a compound of the invention.
Bibliography:Application Number: US201815896779