Polysaccharide and uses thereof

Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier p...

Full description

Saved in:
Bibliographic Details
Main Authors Kowarik, Michael T, Gambillara, Veronica, Kemmler, Stefan J, Häuptle, Micha A, Mally, Manuela, Wetter, Michael L
Format Patent
LanguageEnglish
Published 15.10.2019
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Online AccessGet full text

Cover

Abstract Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
AbstractList Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used in O25B production. The host cells provided herein produce O25B bioconjugates, wherein said bioconjugates contain O25B linked to a carrier protein. Further provided herein are compositions, e.g., pharmaceutical compositions, including O25B and/or bioconjugates containing O25B. Such compositions can be used as vaccines against infection with ExPEC, and may further include one or more additional bioconjugates.
Author Wetter, Michael L
Mally, Manuela
Häuptle, Micha A
Kemmler, Stefan J
Gambillara, Veronica
Kowarik, Michael T
Author_xml – fullname: Kowarik, Michael T
– fullname: Gambillara, Veronica
– fullname: Kemmler, Stefan J
– fullname: Häuptle, Micha A
– fullname: Mally, Manuela
– fullname: Wetter, Michael L
BookMark eNrjYmDJy89L5WSQD8jPqSxOTE7OSCzKTElVSMxLUSgtTi1WKMlILUrNT-NhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGhwYYGJiaGZibmTkbGxKgBAA2lJtk
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US10441647B2
GroupedDBID EVB
ID FETCH-epo_espacenet_US10441647B23
IEDL.DBID EVB
IngestDate Fri Oct 04 05:05:34 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US10441647B23
Notes Application Number: US201715643788
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191015&DB=EPODOC&CC=US&NR=10441647B2
ParticipantIDs epo_espacenet_US10441647B2
PublicationCentury 2000
PublicationDate 20191015
PublicationDateYYYYMMDD 2019-10-15
PublicationDate_xml – month: 10
  year: 2019
  text: 20191015
  day: 15
PublicationDecade 2010
PublicationYear 2019
RelatedCompanies GLAXOSMITHKLINE BIOLOGICALS S.A
GLAXOSMITHKLINE CIOLOGICALS S.A
RelatedCompanies_xml – name: GLAXOSMITHKLINE CIOLOGICALS S.A
– name: GLAXOSMITHKLINE BIOLOGICALS S.A
Score 3.2357812
Snippet Provided herein is a novel E. coli O polysaccharide, O25B. Also provided herein are prokaryotic host cells containing enzymes (e.g., glycosyltransferases) used...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Title Polysaccharide and uses thereof
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20191015&DB=EPODOC&locale=&CC=US&NR=10441647B2
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dS8NALIwp6ptORedXBelbkbbX1j4UoV8MYVtxq-xttNcrKNIO2yH-e5Ojc77o23EHuSSQr8slAbjLcje3HV1oemlwjVGdT2ZTwrFw3ILnlsPlmM7xxB6l7GlhLXrwtqmFkX1CP2VzRJQojvLeSn292j5ihfJvZXOfv-JW_RjPvVDtomMMPtC8qaHvRck0nAZqEHjpTJ0805BbRq2zfFTXO-RGU5_96MWnqpTVb5MSH8JugtCq9gh6ohrAfrCZvDaAvXGX8MZlJ3vNMdwk9ftXk3Gqk0LMlawqlHUjGoVcOFGXJ3AbR_NgpOFNyx-ylulsi5R5Cn0M98UZKGbJLCSCc3R0GONoLoQwhPnAXaMokcRzGP4NZ_jf4QUcEItI8-rWJfTbj7W4QpPa5teSF99bhHnc
link.rule.ids 230,309,786,891,25594,76903
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSUyyTDIzN0zVNUwzStY1Ae3zSTQDTTimmFumJCeZmieDr-n09TPzCDXxijCNYGLIgu2FAZ8TWg4-HBGYo5KB-b0EXF4XIAaxXMBrK4v1kzKBQvn2biG2LmrQ3jGw8wGs3tRcnGxdA_xd_J3VnJ1tQ4PV_IJAl9yagI7OcgIW16zmwC4huKsU5gTalVKAXKW4CTKwBQBNyysRYmBKzRNm4HSG3bwmzMDhC53wBjKhea9YhEE-ID-nsjgxGbRPCuhyhcS8FIXS4tRiBVATLjU_TZRB0c01xNlDF2hTPNxb8aHBCEcZizGwALv7qRIMCsZpJqZATyQnAxs6JibJwOoiNdUo1dgi2dIoJQ3oRUkGKdzmSOGTlGfg9Ajx9Yn38fTzlmbgAgUXqBQ2NJVhYCkpKk2VBVavJUly4HABADLmfMY
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Polysaccharide+and+uses+thereof&rft.inventor=Kowarik%2C+Michael+T&rft.inventor=Gambillara%2C+Veronica&rft.inventor=Kemmler%2C+Stefan+J&rft.inventor=H%C3%A4uptle%2C+Micha+A&rft.inventor=Mally%2C+Manuela&rft.inventor=Wetter%2C+Michael+L&rft.date=2019-10-15&rft.externalDBID=B2&rft.externalDocID=US10441647B2