Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermedia...

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Main Authors Lovering, Frank Eldridge, Allais, Christophe Philippe, Owen, Dafydd Rhys, Mathias, John Paul, Papaioannou, Nikolaos, Gavrin, Lori Krim, Dehnhardt, Christoph Martin, Zapf, Christoph Wolfgang, Lee, Katherine Lin, Han, Seungil, Lee, Arthur, Hepworth, David, Wright, Stephen Wayne, Trzupek, John David, Saiah, Eddine, Strohbach, Joseph Walter
Format Patent
LanguageEnglish
Published 11.06.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula IIc to IIi, IIl to IIv or IIx as defined in the claims. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
Bibliography:Application Number: US201816206166