CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a , R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type...

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Main Authors Chang, Wonsuk, Otte, Ryan, D, Jewell, James, P, Zhao, Kake, Walsh, Shawn, P, Liang, Rui, Lu, Min, Trotter, Benjamin Wesley, Altman, Michael, D, Lim, Jongwon, Siu, Tony, Truong, Quang, T, Liu, Hong, Henderson, Timothy, J, Childers, Matthew Lloyd, Andresen, Brian, Northrup, Alan, B, Cumming, Jared, N, Haidle, Andrew Marc
Format Patent
LanguageEnglish
Ukrainian
Published 19.05.2021
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Abstract A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a , R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
AbstractList A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a , R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Author Zhao, Kake
Jewell, James, P
Haidle, Andrew Marc
Otte, Ryan, D
Liang, Rui
Chang, Wonsuk
Lu, Min
Andresen, Brian
Liu, Hong
Truong, Quang, T
Childers, Matthew Lloyd
Cumming, Jared, N
Altman, Michael, D
Walsh, Shawn, P
Lim, Jongwon
Henderson, Timothy, J
Trotter, Benjamin Wesley
Siu, Tony
Northrup, Alan, B
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– fullname: Lu, Min
– fullname: Trotter, Benjamin Wesley
– fullname: Altman, Michael, D
– fullname: Lim, Jongwon
– fullname: Siu, Tony
– fullname: Truong, Quang, T
– fullname: Liu, Hong
– fullname: Henderson, Timothy, J
– fullname: Childers, Matthew Lloyd
– fullname: Andresen, Brian
– fullname: Northrup, Alan, B
– fullname: Cumming, Jared, N
– fullname: Haidle, Andrew Marc
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Snippet A class of polycyclic compounds of general formula (I), of general formula (II), or of general formula (Io), wherein Base1. Base2, Y, Yа, Xa, Xa1, Xb, Xb1, Xc,...
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Title CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
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