Process for the preparation of polymorph form b of treprostinil diethanolamine salt

• Main Authors: KARDOS, ZSUZSANNA, RITZ, IMOLA, HORTOBAGYI, IREN, VARGA, ZOLTAN, JUHASZ, IMRE, LASZLOFI, ISTVAN
• Format: Patent
• Language: Chinese; English
• Published: 11.12.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a robust and reproducible process for the preparation of polymorph form B of treprostinil diethanolamine salt, comprising the following steps: a. treprostinil is dissolved in methanol, b. to the solution of step a) diethanolamine or its methanol solution is added, c. the rea...