Macrocyclic broad spectrum antibiotics

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for t...

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Main Authors HU, HUIYONG, SCHWARZ, JACOB BRADLEY, HIGUCHI, ROBERT I, KOEHLER, MICHAEL F. T, CRAWFORD, JAMES JOHN, YU, ZHIYONG, HANAN, EMILY J, LY, CUONG Q, CHEN, YONGSHENG, SMITH, PETER ANDREW, ROBERTS, TUCKER CURRAN, PARASELLI, PRASUNA
Format Patent
LanguageChinese
English
Published 21.04.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
AbstractList Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Author HU, HUIYONG
YU, ZHIYONG
HIGUCHI, ROBERT I
CRAWFORD, JAMES JOHN
LY, CUONG Q
ROBERTS, TUCKER CURRAN
HANAN, EMILY J
SMITH, PETER ANDREW
CHEN, YONGSHENG
KOEHLER, MICHAEL F. T
PARASELLI, PRASUNA
SCHWARZ, JACOB BRADLEY
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– fullname: YU, ZHIYONG
– fullname: HANAN, EMILY J
– fullname: LY, CUONG Q
– fullname: CHEN, YONGSHENG
– fullname: SMITH, PETER ANDREW
– fullname: ROBERTS, TUCKER CURRAN
– fullname: PARASELLI, PRASUNA
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RelatedCompanies RQX PHARMACEUTICALS, INC
GENENTECH, INC
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Snippet Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Macrocyclic broad spectrum antibiotics
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