Novel diketopiperazine derivatives as oxytocin receptor antagonists
Compounds of formula (I) wherein R 1 is 2-indanyl, R 2 is 1-methylpropyl, R 3 is a group selected from 2, 6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R 4 represents methyl and R 5 represents hydrogen or methyl or, R 4 and R 5 together with the nitrogen atom to which they are attached represent m...
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| Main Authors | , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
11.09.2011
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Compounds of formula (I)
wherein R 1 is 2-indanyl, R 2 is 1-methylpropyl, R 3 is a group selected from 2, 6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R 4 represents methyl and R 5 represents hydrogen or methyl or, R 4 and R 5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists. |
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| AbstractList | Compounds of formula (I)
wherein R 1 is 2-indanyl, R 2 is 1-methylpropyl, R 3 is a group selected from 2, 6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R 4 represents methyl and R 5 represents hydrogen or methyl or, R 4 and R 5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described, as are processes for their preparation, pharmaceutical compositions containing them and their use in medicine, particularly their use as oxytocin antagonists. |
| Author | LIDDLE, JOHN HICKEY, DEIRDRE MARY BERNADETTE MASON, ANDREW MCMURTRIE BORTHWICK, ALAN DAVID |
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| Snippet | Compounds of formula (I)
wherein R 1 is 2-indanyl, R 2 is 1-methylpropyl, R 3 is a group selected from 2, 6-dimethyl-3-pyridyl or 4,6-dimethyl-3-pyridyl, R 4... |
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| Title | Novel diketopiperazine derivatives as oxytocin receptor antagonists |
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