N-terminally monopegylated human growth hormone conjugates and process for their preparation
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activ...
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Main Author | |
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Format | Patent |
Language | English |
Published |
01.06.2007
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides a chemically modified human Growth Hormone (hGH) prepared by attaching a polyethylene glycol butyraldehyde moiety to the N-terminal phenylalanine of the protein. The chemically-modified protein according to the present invention may have a much longer lasting hGH activity than that of the un-modified hGH, enabling reduced dose and scheduling opportunities. |
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Bibliography: | Application Number: TW200392132405 |