Process for the preparation of taxane derivatives

• Main Authors: DIDIER, ERIC, COMMERCON, ALAIN, FOUQUE, ELIE
• Format: Patent
• Language: English
• Published: 11.06.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Taxane derivatives of formula (I) are prepared by esterification of protected baccatin III or protected 10-deacetyl-baccatin III with an acid of formula (VII) removal of the protective groups and acylation of the amine functional group of the side chain. The products of formula (I) have notable anti...