Antibody-drug conjugates targeting glypican-3 and methods of use

Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.

Saved in:
Bibliographic Details
Main Authors BARNSCHER, STUART DANIEL, PETERSEN, MARK EDMUND, COLOMBO, RAFFAELE, WU, ALEX MAN LAI, LASALLE, MANUEL MICHEL AUGUSTE, RICH, JAMES R, UROSEV, DUNJA, HERNANDEZ ROJAS, ANDREA, DAS, SAMIR, ALONZO MUNIZ, DIEGO ARTURO, PISCITELLI, CHAYNE L, BRANT, MICHAEL G
Format Patent
LanguageChinese
English
Published 01.07.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
AbstractList Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
Author ALONZO MUNIZ, DIEGO ARTURO
HERNANDEZ ROJAS, ANDREA
RICH, JAMES R
BRANT, MICHAEL G
WU, ALEX MAN LAI
BARNSCHER, STUART DANIEL
PISCITELLI, CHAYNE L
PETERSEN, MARK EDMUND
LASALLE, MANUEL MICHEL AUGUSTE
UROSEV, DUNJA
COLOMBO, RAFFAELE
DAS, SAMIR
Author_xml – fullname: BARNSCHER, STUART DANIEL
– fullname: PETERSEN, MARK EDMUND
– fullname: COLOMBO, RAFFAELE
– fullname: WU, ALEX MAN LAI
– fullname: LASALLE, MANUEL MICHEL AUGUSTE
– fullname: RICH, JAMES R
– fullname: UROSEV, DUNJA
– fullname: HERNANDEZ ROJAS, ANDREA
– fullname: DAS, SAMIR
– fullname: ALONZO MUNIZ, DIEGO ARTURO
– fullname: PISCITELLI, CHAYNE L
– fullname: BRANT, MICHAEL G
BookMark eNrjYmDJy89L5WRwcMwryUzKT6nUTSkqTVdIzs_LKk1PLEktVihJLEpPLcnMS1dIz6ksyExOzNM1VkjMS1HITS3JyE8pVshPUygtTuVhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfEh4UYGRiZGZgamFo7GxKgBANr1MwQ
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID TW202426058A
GroupedDBID EVB
ID FETCH-epo_espacenet_TW202426058A3
IEDL.DBID EVB
IngestDate Fri Oct 18 06:05:12 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language Chinese
English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_TW202426058A3
Notes Application Number: TW202312139841
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240701&DB=EPODOC&CC=TW&NR=202426058A
ParticipantIDs epo_espacenet_TW202426058A
PublicationCentury 2000
PublicationDate 20240701
PublicationDateYYYYMMDD 2024-07-01
PublicationDate_xml – month: 07
  year: 2024
  text: 20240701
  day: 01
PublicationDecade 2020
PublicationYear 2024
RelatedCompanies ZYMEWORKS BC INC
RelatedCompanies_xml – name: ZYMEWORKS BC INC
Score 3.6834273
Snippet Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue...
SourceID epo
SourceType Open Access Repository
SubjectTerms HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title Antibody-drug conjugates targeting glypican-3 and methods of use
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240701&DB=EPODOC&locale=&CC=TW&NR=202426058A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSTZIAlb7hsa6iYkpybomyeapuqDZKV0Tc4M0UwuDRGAbFtRR9PUz8wg18YowjWBiyILthQGfE1oOPhwRmKOSgfm9BFxeFyAGsVzAayuL9ZMygUL59m4hti5q0N4xqHsC7Bu7ONm6Bvi7-DurOTvbhoSr-QWB5UBNdwtHZgZWYDPaHJQbXMOcQLtSCpCrFDdBBrYAoGl5JUIMTFUZwgyczrCb14QZOHyhE95AJjTvFYswODjmlWQm5adU6qYUlaYrAPuxWaWgMbBiBchqbmAdpJCeU1kAKtd0jRUS81IUINdDFyvkpymUFqeKMii6uYY4e-gCnRIP93d8SDjC1cZiDCx5-XmpEgwKpkZJwK5fUmKKUYqBSaqZiWWKqWmihYmlhSWwqWCWZCTJIIXbHCl8ktIMXCAOZDWqDANLSVFpqiywzi1JkgMHFgAY4YVb
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8gGvFNUaP4VROzt8a5L8YDUdggqHzFTOGNrOtAiNkWtsXgX-91gPiib00vuVyb3P3u116vADeezBD271Tqutyjmlf2qbidolpZHuum7GIOK4hip2u0XrWnoT7MwWz9FibrE_qZNUdEj_LQ35MsXkebQyw7q62Mb9kUp8L7plO1pRU7FvQEubFdrzb6PbtnSZZVdQZS9yWTidTdrG3BNqbYZeENjbe6eJUS_YaU5j7s9FFbkBxA7uu9CAVr_fNaEXY7qwtvHK58Lz6Eh1qQTFnIF5TP0wlBHjtLxRlYTJbV3IhBZPKxiERcoypxA06W30PHJByTNPaP4LrZcKwWRVNGP-seOYON1eox5IMw8E-A6ApD6sdcrnBZ8w2twnXdNbWKWcFUwWDKKZT-1lP6T3gFhZbTaY_aj93nM9gTgmVl6jnkk3nqXyD-Juwy27hvhaKITg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Antibody-drug+conjugates+targeting+glypican-3+and+methods+of+use&rft.inventor=BARNSCHER%2C+STUART+DANIEL&rft.inventor=PETERSEN%2C+MARK+EDMUND&rft.inventor=COLOMBO%2C+RAFFAELE&rft.inventor=WU%2C+ALEX+MAN+LAI&rft.inventor=LASALLE%2C+MANUEL+MICHEL+AUGUSTE&rft.inventor=RICH%2C+JAMES+R&rft.inventor=UROSEV%2C+DUNJA&rft.inventor=HERNANDEZ+ROJAS%2C+ANDREA&rft.inventor=DAS%2C+SAMIR&rft.inventor=ALONZO+MUNIZ%2C+DIEGO+ARTURO&rft.inventor=PISCITELLI%2C+CHAYNE+L&rft.inventor=BRANT%2C+MICHAEL+G&rft.date=2024-07-01&rft.externalDBID=A&rft.externalDocID=TW202426058A