Antibody-drug conjugates targeting glypican-3 and methods of use

Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.

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Bibliographic Details
Main Authors BARNSCHER, STUART DANIEL, PETERSEN, MARK EDMUND, COLOMBO, RAFFAELE, WU, ALEX MAN LAI, LASALLE, MANUEL MICHEL AUGUSTE, RICH, JAMES R, UROSEV, DUNJA, HERNANDEZ ROJAS, ANDREA, DAS, SAMIR, ALONZO MUNIZ, DIEGO ARTURO, PISCITELLI, CHAYNE L, BRANT, MICHAEL G
Format Patent
LanguageChinese
English
Published 01.07.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are antibody-drug conjugates (ADCs) comprising an antibody construct that binds human glypican 3 (GPC3) conjugated to a camptothecin analogue of Formula (I). The ADCs are useful as therapeutics, in particular in the treatment of cancer.
Bibliography:Application Number: TW202312139841