Novel anti-A2AP antibodies and uses thereof

The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention (i) cross-reacts with rabbit and/or cynomolgus A2AP, (ii) does not inhibit human plasmin activity,...

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Main Authors WILMEN, ANDREAS, GLUNZ, JULIA, JOERISSEN, HANNAH, THIEL, CHRISTOPH, WEBER, ERNST, SCHULENBURG, CINDY, HEITMEIER, STEFAN, FISCHER, MELANIE
Format Patent
LanguageChinese
English
Published 16.07.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention (i) cross-reacts with rabbit and/or cynomolgus A2AP, (ii) does not inhibit human plasmin activity, and (iii) increases plasmin mediated clot lysis in the presence of A2AP.
Bibliography:Application Number: TW202110133977