Single-domain antibodies against CLL1 and constructs thereof
The present application provides single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and opt...
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| Main Authors | , , , , , , , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
16.10.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present application provides single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided. |
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| AbstractList | The present application provides single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided. |
| Author | TU, XIAO-JIE SHU, CHEN-YU ZHANG, QING ZHANG, YUN ZHANG, WANG TANG, AN ZHAN, TAI-LAN WU, SHU ZHANG, YA-FENG LIU, YUN-LEI |
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| Notes | Application Number: TW20198132631 |
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| RelatedCompanies | NANJING LEGEND BIOTECH CO., LTD |
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| Snippet | The present application provides single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | Single-domain antibodies against CLL1 and constructs thereof |
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