Monocyclic pyridine derivative

• Main Authors: FUNASAKA, SETSUO, OKADA, TOSHIMI, TANAKA, KEIGO, OHASHI, ISAO, NAGAO, SATOSHI, YAMANE, YOSHINOBU, NAKATANI, YUSUKE, KAROJI, YUKI
• Format: Patent
• Language: Chinese; English
• Published: 01.01.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same,. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or -CH2-; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group, an alkoxy alkoxy group or the like; R2 represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group, a hydroxy alkyl group, a nitrogen-containing non-aromatic heterocyclic group or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.